Currents in Trigeminal Ganglion Neurons + Eugenol Inhibits
نویسندگان
چکیده
منابع مشابه
Eugenol inhibits K+ currents in trigeminal ganglion neurons.
UNLABELLED Eugenol, a natural capsaicin congener, is widely used in dentistry. Eugenol inhibits voltage-activated Na(+) and Ca(2+) channels in a transient receptor potential vanilloid 1 (TRPV1)-independent manner. We hypothesized that eugenol also inhibits voltage-gated K(+) currents, and investigated this in rat trigeminal ganglion neurons and in a heterologous system using whole-cell patch cl...
متن کاملEugenol Inhibits ATP-induced P2X Currents in Trigeminal Ganglion Neurons.
Eugenol is widely used in dentistry to relieve pain. We have recently demonstrated voltage-gated Na(+) and Ca(2+) channels as molecular targets for its analgesic effects, and hypothesized that eugenol acts on P2X(3), another pain receptor expressed in trigeminal ganglion (TG), and tested the effects of eugenol by whole-cell patch clamp and Ca(2+) imaging techniques. In the present study, we inv...
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Eugenol has sedative, antioxidant, anti-inflammatory, and analgesic effects, but also serves as an irritant through the regulation of a different set of ion channels. Activation of gamma aminobutyric acid (GABA) receptors on sensory neurons leads to the stabilization of neuronal excitability but contributes to formalin-induced inflammatory pain. In this study, we examined the effect of eugenol ...
متن کاملEffects of Eugenol on T-type Ca Channel Isoforms
Eugenol has been used as an analgesic in dentistry. Previous studies have demonstrated that voltage-gated Na channels and high-voltage-activated Ca channels expressed in trigeminal ganglion (TG) neurons sensing dental pain are molecular targets of eugenol for its analgesic effects. However, it has not been investigated whether eugenol can affect T-type Ca channels, which are known to be detecte...
متن کاملEffects of eugenol on T-type Ca2+ channel isoforms.
Eugenol has been used as an analgesic in dentistry. Previous studies have demonstrated that voltage-gated Na(+) channels and high-voltage-activated Ca(2+) channels expressed in trigeminal ganglion (TG) neurons sensing dental pain are molecular targets of eugenol for its analgesic effects. However, it has not been investigated whether eugenol can affect T-type Ca(2+) channels, which are known to...
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تاریخ انتشار 2007